Cervical Cancer Screening in South Florida Veteran Population, 2014 to 2020: Cytology and High-Risk Human Papillomavirus Correlation and Epidemiology

Objective This project aims to use our robust women's health patient data analyze the correlation between cytology and high-risk human papillomavirus (Hr-HPV) testing, study performance of Hr-HPV testing for detecting lesions, examine epidemiologic measures (HPV) infections in veteran population. Methods We collected from 2014 2020 computerized record system. performed HPV assays using cobas® 4800 system (Roche Diagnostics, Basel, Switzerland). The cobas assay detects 16, 18, 12 other types (31, 33, 35, 39, 45, 51, 56, 58, 59, 66, 68). organized results with Microsoft Access Excel (Microsoft Corporation, Washington, USA) analysis. Results A total 9437 cervical specimens were co-tested. High-grade lesions - high-grade intraepithelial lesion (HSIL) or higher atypical squamous cells, cannot exclude HSIL (ASC-H) overwhelmingly positive (94.1% 87.2%, respectively). Low-grade low-grade ((LSIL) cells undetermined significance (ASC-US) lower percentages (72.6% 54.9%, had a sensitivity 91.3%, specificity 93.1%, predictive value 16.4%, negative 99.8% lesions. Ten cases test. Out 10 such patients, nine showed no dysplasia (six) (three) on subsequent biopsy. Overall, 14.4% tests Hr-HPV. highest test rates third eighth decades life, 25.1% 22.0%, respectively. However, decade consisted small sample only 50 women. In women over 30 years age infections, 16 18 present 11.7% 6.4% tests, Other 82.3% tests. Conclusions has high studies show that LSIL rarely progresses neoplasia grade 3 (CIN3+), suggesting minimal impact cancer screening. believe findings are accordance recent affirm guidelines recommend primary as preferred screening method. percentage women’s population suggest similar prevalence general US